Fundamentals of Nursing Practice · Oxygenation
Oxygen Therapy and Noninvasive Ventilation Concepts
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In 30 seconds
Oxygen therapy Prescribed oxygen above room air Full entry → delivers oxygen at a concentration above room air to correct or prevent hypoxemia, guided by the fraction of inspired oxygen (FiO2 Fraction of inspired oxygen Full entry →). Devices range from the Nasal cannula Nasal prongs delivering oxygen Full entry → and Simple face mask Mask over nose and mouth Full entry → to partial-rebreather, Non-rebreather Mask with valves and reservoir bag Full entry →, and Venturi masks, each offering a different concentration and precision. Because oxygen supports combustion, safety is paramount; noninvasive ventilation with CPAP Continuous positive airway pressure Full entry → or BiPAP Bilevel positive airway pressure Full entry → provides positive airway pressure without an artificial airway and requires Monitoring Tracking SpO2, effort, tolerance Full entry →, skin care, and Respiratory-therapy collaboration Team-based device management Full entry →.
Why this matters
Oxygen therapy and noninvasive ventilation are among the most common yet most safety-sensitive nursing interventions, requiring clear orders, accurate documentation, and vigilance for under- and over-oxygenation. Nurses advocate for Comfort Reducing anxiety, improving fit Full entry → and dignity, protect skin under interfaces, and ensure safety precautions are respected. Because oxygen is regulated as a medical gas, and flow rates, concentrations, NIV settings, and documentation standards vary by jurisdiction, institution, and patient condition, learners must follow provider orders, institutional policy, and supervised clinical training. Worsening respiratory status requires institutional escalation or local emergency services.
The college version
1. Oxygen therapy and FiO2
Oxygen therapy is the prescribed administration of oxygen above room air to treat or prevent hypoxemia. It is a treatment, not a comfort measure, so it is ordered, monitored, and titrated. FiO2 — the fraction of inspired oxygen — expresses how much of each breath is oxygen; room air is about 0.21, and delivered oxygen raises this fraction. The goal is enough oxygen to meet tissue needs without excess, since excessive oxygen can harm some individuals.
2. Delivery devices
- Nasal cannula — two prongs in the nostrils; a low-to-moderate concentration that is comfortable and allows eating and talking.
- Simple face mask — a mask over the nose and mouth; a moderate step up.
- Partial rebreather Mask with reservoir bag, some rebreathing Full entry → mask — a mask with a reservoir bag that lets some exhaled air return, raising the concentration further.
- Non-rebreather mask — a mask with a reservoir bag and one-way valves that delivers a high concentration for higher-need situations.
- Venturi mask Mask delivering a precise concentration Full entry → — uses a venturi mechanism to entrain a precise, predictable concentration, useful when the exact FiO2 matters.
Device selection balances the needed concentration against comfort, breathing pattern, skin tolerance, and the ability to keep the device in place; exact flows and concentrations are ordered and titrated by qualified clinicians per policy. Humidification adds moisture to delivered oxygen to protect airway tissues.
3. Oxygen safety and noninvasive ventilation
Oxygen safety is critical because oxygen supports combustion: fire risk rises near flames, sparks, and petroleum-based products, and policies restrict smoking and ignition sources. Noninvasive ventilation (NIV) delivers positive airway pressure through a mask instead of an artificial airway: CPAP (continuous positive airway pressure) delivers one steady pressure through the cycle, while BiPAP (bilevel positive airway pressure) delivers a higher pressure on inspiration and a lower one on expiration. NIV monitoring includes SpO2, breathing effort, and tolerance; skin integrity is protected by well-fitted, padded interfaces and skin checks; and comfort and anxiety management improve adherence. Respiratory-therapy collaboration is essential for device selection, settings, and troubleshooting.
How it works
- Oxygen is prescribed to raise the fraction of inspired oxygen (FiO2) above room air when the body cannot maintain adequate oxygenation.
- A device is selected to provide the needed concentration while preserving comfort and function.
- Humidification protects airway tissues, and safety rules prevent fire risk near the oxygen source.
- When positive pressure is needed, CPAP or BiPAP props the airway open without an artificial airway.
- Throughout, the nurse monitors oxygenation, protects skin, supports comfort, and collaborates with respiratory therapy, adjusting settings only as ordered.
Common confusions
| Do not confuse | With | Difference |
|---|---|---|
| Nasal cannula | Simple face mask | Cannula is low-to-moderate and comfortable; the mask delivers more |
| Partial rebreather | Non-rebreather | Both have a reservoir bag; the non-rebreather's valves deliver a higher concentration |
| CPAP | BiPAP | CPAP is one continuous pressure; BiPAP is two pressures |
| FiO2 | Flow rate | FiO2 is the concentration; flow rate is the volume per minute set |
| Noninvasive ventilation | Mechanical ventilation | NIV uses a mask; mechanical ventilation uses an artificial airway |
| Humidification | Nebulization | Humidification moistens gas; nebulization delivers aerosolized medication |
Memory aids
For the mask devices in order of increasing oxygen concentration: "Simple People Never Ventilate" — Simple mask, Partial rebreather, Non-rebreather, Venturi (precise). And CPAP = Continuous pressure; BiPAP = two (Bi) levels.
Quick review
Topic Recap
- Oxygen therapy raises the fraction of inspired oxygen (FiO2) above room air to treat or prevent hypoxemia and is always ordered and monitored.
- Devices — nasal cannula, simple, partial-rebreather, non-rebreather, and Venturi masks — differ in concentration and precision.
- Oxygen safety and fire risk are paramount; humidification protects airway tissues.
- Noninvasive ventilation (CPAP and BiPAP) provides positive pressure without an artificial airway and requires monitoring, skin protection, and comfort support.
- Respiratory-therapy collaboration is central to device choice, settings, and troubleshooting.
Knowledge Check
- What does FiO2 represent, and what is its approximate value in room air?
- Which device delivers the highest oxygen concentration among the mask options, and which delivers the most precise concentration?
- Why is fire risk a major concern with oxygen therapy?
- How do CPAP and BiPAP differ?
- Why must oxygen settings be ordered and titrated by a qualified clinician rather than chosen independently by the nurse?
Answers and Rationales
- Answer: FiO2 is the fraction of inspired oxygen; room air is about 0.21 (21%). Why: It is the measure of how much of each breath is oxygen.
- Answer: The non-rebreather delivers the highest concentration; the Venturi mask delivers the most precise, predictable concentration. Why: The non-rebreather's valves and bag concentrate oxygen; the Venturi entrains an exact mixture.
- Answer: Oxygen supports combustion, so flames, sparks, and smoking near oxygen can cause serious fire and burns. Why: Safety precautions and signage are essential around any oxygen source.
- Answer: CPAP delivers one continuous pressure; BiPAP delivers two — higher on inspiration, lower on expiration. Why: This distinction guides device selection for different breathing needs.
- Answer: Oxygen is a prescribed treatment, and the correct concentration and flow depend on the individual's condition; too much or too little oxygen can harm. Why: Nurses administer oxygen as ordered and monitor its effects.

Eli explains
The same idea, in plain words
Explain it like I’m 10
Think of oxygen as a gas you can turn up like a faucet, and the device as the nozzle controlling how much reaches the lungs. A nasal cannula is a light spray; a simple face mask is a fuller stream; a non-rebreather is a high-flow firehose with a reservoir bag so the person breathes a high concentration; and a Venturi mask is a precision nozzle delivering an exact mixture.
FiO2 is simply "what fraction of each breath is oxygen" — room air is about 21% (written 0.21), and therapy raises that fraction. CPAP and BiPAP add a steady push of air pressure to keep the airway propped open, without any tube down the throat. This comparison stops being exact because oxygen is a prescribed treatment, not a comfort faucet — flow and concentration are ordered, monitored, and titrated by qualified clinicians, and too much oxygen can itself be harmful.
Simple Example
Choosing a device is like choosing a spray setting: a gentle mist (cannula), a steady stream (mask), or a precision mixture (Venturi) — and CPAP/BiPAP is an air pillow that holds the airway open while you breathe.
Worked example
- Assess (observe): monitor SpO2, respiratory rate and effort, work of breathing, and — during NIV — mask fit, air leak, skin under the interface, comfort, and anxiety.
- Interpret and plan: compare current oxygenation to baseline and the prescribed target, and plan comfort, positioning, and skin protection while recognizing that oxygen settings are ordered, not independently chosen.
- Implement: ensure the device is correctly applied and humidified, promote a tolerable fit, protect skin at pressure points, and reassure; flow, concentration, and pressure settings are adjusted only as ordered.
- Document: record SpO2, respiratory status, the device and its ordered settings, skin condition, and response and tolerance.
- Communicate and escalate: report worsening oxygenation, rising work of breathing, mask intolerance, or skin breakdown, and collaborate with respiratory therapy; urgent deterioration requires escalation.
Key takeaways
- High yield: Oxygen is a prescribed treatment, not a comfort measure — flow and concentration are ordered, monitored, and titrated.
- High yield: FiO2 is the fraction of inspired oxygen; room air is about 0.21, and therapy raises that fraction.
- High yield: Oxygen supports combustion — no smoking and no open flames or sparks near oxygen.
- The non-rebreather delivers the highest concentration among mask devices; the Venturi delivers the most precise.
- CPAP is one steady pressure; BiPAP is two pressures (higher in, lower out).
- Skin under NIV interfaces is a common pressure-injury site — assess and protect it regularly.
Study tools & related lessonsYou’ll learn to · Key vocabulary · Related
You’ll learn to
- Explain the purpose of oxygen therapy and the concept of FiO2.
- Compare oxygen delivery devices — nasal cannula, simple face mask, partial rebreather, non-rebreather, and Venturi mask — and the principles of device selection.
- Describe oxygen safety, including fire risk, and the role of humidification.
- Summarize noninvasive ventilation (CPAP and BiPAP), its monitoring, and related skin-integrity and comfort considerations.
Key vocabulary
- Oxygen therapy
- Prescribed oxygen above room air
- Oxygen safety
- Precautions because oxygen supports combustion
- Fire risk
- Danger from flames/sparks near oxygen
- Nasal cannula
- Nasal prongs delivering oxygen
- Simple face mask
- Mask over nose and mouth
- Partial rebreather
- Mask with reservoir bag, some rebreathing
- Non-rebreather
- Mask with valves and reservoir bag
- Venturi mask
- Mask delivering a precise concentration
- Device selection
- Matching device to need and tolerance
- FiO2
- Fraction of inspired oxygen
- Humidification
- Adding moisture to oxygen
- CPAP
- Continuous positive airway pressure
- BiPAP
- Bilevel positive airway pressure
- Monitoring
- Tracking SpO2, effort, tolerance
- Skin integrity
- Protecting skin under masks
- Comfort
- Reducing anxiety, improving fit
- Respiratory-therapy collaboration
- Team-based device management
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