Pathophysiology · ELI Explains: Respiratory Pathophysiology (book 3)
Pneumonia
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The college version
Clinical Orientation
A 78-year-old nursing home resident is admitted with fever (39.1°C), cough productive of green sputum, and SpO2 86% on room air. Chest X-ray shows right lower lobe consolidation. She is confused — her baseline is alert. This is community-acquired pneumonia. This chapter answers: What mechanism links pneumonia to bedside findings, tests, red flags, and nursing priorities?
What Goes Wrong?
Pneumonia = infection of the lung parenchyma (alveoli and interstitium).
Pathogenesis: Organisms reach the lower respiratory tract (aspiration, inhalation, hematogenous spread) → overcome host defenses (cough, mucociliary clearance, alveolar macrophages) → multiply in alveoli → trigger inflammatory response.
The inflammatory exudate: Neutrophils, bacteria, fluid, and fibrin fill the alveoli → consolidation → that segment of lung becomes airless. Blood continues to flow past these fluid-filled alveoli → intrapulmonary shunt → severe hypoxemia that is relatively resistant to supplemental O2.
Classification:
- Community-acquired (CAP): S. pneumoniae (most common), H. influenzae, atypical (Mycoplasma, Chlamydia, Legionella), viral (influenza, RSV, SARS-CoV-2).
- Hospital-acquired (HAP): Onset ≥48 hours after admission. More resistant organisms — Pseudomonas, MRSA, Enterobacteriaceae.
- Ventilator-associated (VAP): Onset ≥48 hours after intubation.
- Aspiration pneumonia: Chemical pneumonitis from gastric contents + possible bacterial infection. Anaerobes common.
What the Nurse May See
- Respiratory: Tachypnea, dyspnea, cough (productive or nonproductive). Crackles, bronchial breath sounds (consolidation), egophony, increased tactile fremitus over the affected area.
- Systemic: Fever, chills, malaise, myalgia.
- Elderly/immunocompromised: May present with confusion, weakness, falls, decreased oral intake WITHOUT fever or cough. High index of suspicion needed.
- Sepsis progression: Hypotension, tachycardia, altered mental status, rising lactate.
Tests and Monitoring
- Chest X-ray: Infiltrate/consolidation confirms pneumonia. May show lobar (one lobe), bronchopneumonia (patchy), or interstitial pattern.
- Sputum culture and Gram stain: Identify organism. Obtain BEFORE antibiotics if possible, but do NOT delay antibiotics.
- Blood cultures: For patients with severe CAP or risk of bacteremia.
- CBC: Leukocytosis (or leukopenia — ominous in sepsis).
- ABG or SpO2: Assess oxygenation. Severe pneumonia → shunt → refractory hypoxemia.
- CURB-65 or PSI score: Assess severity and need for hospitalization.
Nursing Priorities
- Oxygenation: Target SpO2 ≥92% (or ≥88-92% in COPD). May require high-flow O2 or noninvasive/invasive ventilation.
- Antibiotics — administer promptly: CAP: within 4-8 hours of arrival. Do NOT delay for sputum collection — obtain cultures, then give antibiotics.
- Secretion management: Encourage cough and deep breathing. Incentive spirometry. Hydration (thins secretions). Position changes. Chest physiotherapy.
- Monitor for sepsis: Frequent vital signs, mental status, urine output. Know the sepsis screening tools.
- Prevention of complications: Parapneumonic effusion/empyema, lung abscess, bacteremia, respiratory failure, sepsis.
- Infection control: Standard precautions + droplet precautions if indicated (influenza, certain pathogens). Hand hygiene.
Red Flags
| Red Flag | Action |
|---|---|
| Sepsis (hypotension, lactate >2, altered mentation) | Sepsis bundle: cultures, lactate, antibiotics, fluids, vasopressors. |
| Rapidly increasing O2 requirement | Worsening shunt. May need intubation. |
| Confusion in elderly | May be the only sign of pneumonia — do not dismiss as "sundowning." |
Key takeaways
- Pneumonia = alveolar infection + inflammatory exudate → consolidation → shunt.
- Elderly may present with confusion alone — no fever, no cough.
- Cultures before antibiotics, but don't delay antibiotics.
- Shunt hypoxemia is relatively O2-resistant.
- ---
Check yourself
1 review question from the chapter. Try each one, then open the answer.
Q1 (Mechanism): Why is hypoxemia in pneumonia often refractory to supplemental oxygen? A. The patient isn't breathing deeply enough B. Shunt: blood flows past consolidated, fluid-filled alveoli without being oxygenated — this blood never sees the supplemental oxygen C. The patient has CO2 retention D. Oxygen toxicity develops
Show answer
B. In pneumonia, alveoli are filled with exudate. Blood perfusing these alveoli cannot be oxygenated — this is a true shunt (V/Q = 0). The shunted blood mixes with oxygenated blood, lowering overall PaO2. Oxygen helps ventilated alveoli but doesn't fix the shunt.
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